Anti-HtrA2 (8G11) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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HTRA2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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8G11-4B8-4F10-G5
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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Recombinant human HtrA2/Omi protein.
Molecular Weight
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Calculated MW: 49 kDa; Observed MW: 37 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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27429
Uniprot ID
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O43464
Background
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High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins. While HtrA2 was orignally identified to be present in either the nucleus or endoplasmic reticulum, subsequent studies have shown that it localizes in mitochondria and is released during apoptosis.
Research Area
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Neuroscience
Synonyms
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High temperature requirement protein A2; HTRA 2; HtrA like serine protease; HtrA serine peptidase 2; HtrA; E. coli; homolog of; 2; HtrA2; HTRA2_HUMAN; mitochondrial; Omi stress regulated endoprotease; Omi stress-regulated endoprotease; PARK 13; PARK13; Protease serine 25; PRSS 25; PRSS25; Serine protease 25; Serine protease HTRA2; Serine protease HTRA2 mitochondrial; Serine protease htra2 mitochondrial precursor; Serine protease omi; Serine proteinase OMI.