Anti-Hspa8 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
HSPA8
Host
Storage
-
Store at 2-8°C for up to 2 weeks. store at -20°C for long term storage in small aliquots. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/2000
Immunogen
-
This DANRE hspa8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide from the C-terminal region of DANRE hspa8.
Molecular Weight
-
Calculated MW:71 kDa; Observed MW: 71 kDa
Formulation
-
Liquid in PBS containing 0.09% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
573376
Uniprot ID
-
Q90473
Background
-
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
Research Area
-
Signal Transduction
Synonyms
-
Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, hspa8, hsc70