Anti-HNF 1 alpha Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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HNF1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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Synthetic peptide of human HNF1A
Molecular Weight
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Calculated MW: 67 kDa; Observed MW: 81 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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6927
Uniprot ID
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P20823
Background
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The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20