Anti-HMGB1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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HMGB1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-8X-2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 FC: 1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW:25 kDa;Observed MW: 29 kDa
Formulation
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Liquid in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Form
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Liquid
Gene ID
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3146
Uniprot ID
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P09429
Background
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High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1