Anti-Histone H2A.X Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2AX
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-5E6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
Immunogen
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A synthetic peptide of human Histone H2A.X
Molecular Weight
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Calculated MW: 15 kDa; Observed MW: 15 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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3014
Uniprot ID
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P16104
Background
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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X