Anti-Histone H1.8 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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H1-8
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Immunogen
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The antiserum was produced against synthesized peptide derived from human Histone H1.
Molecular Weight
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-
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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132243
Uniprot ID
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Q8IZA3
Background
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May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling .
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H1.8; H1oo; osH1