Anti-HIP1 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
HIP1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
1L4-D1-V4
Isotype
-
IgG1/kappa
Reactivity
Application
Application Details
-
WB：1/500-1/1000，ICC/IF：1/50
Immunogen
-
Peptide
Molecular Weight
-
Calculated MW: 116 kDa; Observed MW:116 kDa
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
3092
Uniprot ID
-
O00291
Background
-
HIP1 plays a role in clathrin-mediated endocytosis and trafficking, which is involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It regulates presynaptic nerve terminal activity. It can enhance androgen receptor (AR)-mediated transcription and may act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. It can bind 3-phosphoinositides (via ENTH domain). It is required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Research Area
-
Neuroscience
Synonyms
-
Huntingtin-interacting protein 1