Anti-HDAC8 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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HDAC8
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-2B7
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/30 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human HDAC8
Molecular Weight
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Calculated MW: 42 kDa; Observed MW: 42 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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55869
Uniprot ID
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Q9BY41
Background
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8