Anti-HDAC6 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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HDAC6
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
Immunogen
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A synthesized peptide derived from human HDAC6
Molecular Weight
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Calculated MW: 131 kDa; Observed MW: 160 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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10013
Uniprot ID
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Q9UBN7
Background
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Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6