Anti-HDAC3 (3G3) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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HDAC3
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3G3-H6-H10
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human HDAC3 protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 49 kDa; Observed MW: 49 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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8841
Uniprot ID
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O15379
Background
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HDAC3 is a nuclear and cytoplasmic protein that deacetylates both histone (H2A, H3, H4) and non-histone substrates (RelA, SRY, p53, MEF2, PCAF and p300/CBP). HDAC3 deacetylase activity is stimulated by interactions with the N-CoR and SMRT co-repressor proteins. Together, these three proteins form a functional complex that represses transcription associated with nuclear hormone receptors and other transcription factors, including Rev-Erb, COUP-TF, DAX1, MAD and Pit-1.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45