Anti-GRPR Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
GRPR
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
-
Synthetic peptide of human GRPR
Molecular Weight
-
Calculated MW: 43 kDa; Observed MW: 43 kDa
Formulation
-
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
-
Liquid
Gene ID
-
2925
Uniprot ID
-
P30550
Background
-
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastroinTinal and central nervous systems, including release of gastroinTinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Research Area
-
Neuroscience
Synonyms
-
BB2