Anti-GRK2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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GRK2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R01-1J7
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human GRK2
Molecular Weight
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Calculated MW: 80 kDa; Observed MW: 80 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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156
Uniprot ID
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P25098
Background
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GRK2 kinase activity and cellular localization are tightly regulated by interactions with activated receptors, G-beta and G-gamma subunits, adaptor proteins, phospholipids, caveolin and calmodulin, as well as by phosphorylation. PKC phosphorylation enhances GRK2 activity by promoting its membrane localization and by abolishing the inhibitory association of calmodulin.
Research Area
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Neuroscience
Synonyms
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GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1