Anti-Granzyme B Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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GZMB
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-6A4
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50
Immunogen
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A synthesized peptide derived from human Granzyme B
Molecular Weight
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-
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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3002
Uniprot ID
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P10144
Background
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This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Research Area
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Cell Biology
Synonyms
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Granzyme B; Cathepsin G-like 1; CTSGL1; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; SECT; GZMB; CGL1; CSPB; CTLA1; GRB