Anti-GITR Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TNFRSF18
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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ZN203
Isotype
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IgG2b
Reactivity
Application
Application Details
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IHC: 1/50-1/100
Immunogen
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Human recombinant protein fragment of human TNFRSF18(NP_004186) produced in E.coli.
Molecular Weight
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-
Formulation
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PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Form
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Liquid
Gene ID
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8784
Uniprot ID
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Q9Y5U5
Background
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This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb
Research Area
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Signal Transduction
Synonyms
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AITR; GITR; TNFRSF18; CD357