Anti-GBA Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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GBA
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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ZN171
Isotype
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IgG2a
Reactivity
Application
Application Details
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IHC: 1/50-1/100
Immunogen
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Human recombinant protein fragment of human GBA (NP_000148) produced in E.coli.
Molecular Weight
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-
Formulation
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PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Form
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Liquid
Gene ID
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2629
Uniprot ID
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P04062
Background
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This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Research Area
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Neuroscience
Synonyms
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Alglucerase; betaGC; GBA1; GCase; GCB; GLUC; Glucosylceramidase; Imiglucerase