Anti-GADD45A (6C3) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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GADD45A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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6C3-G3-E9
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human GADD45 α protein expressed in E.coli
Molecular Weight
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Calculated MW: 18 kDa; Observed MW: 22 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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1647
Uniprot ID
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P24522
Background
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This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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DDIT1; GADD45