Anti-GABA A Receptor alpha 1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Gabra1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-6D-3
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 52 kDa; Observed MW:52 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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14394
Uniprot ID
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P62812
Background
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GABA A Receptor alpha 1 is a subunit of the GABA A receptor protein. GABA A receptor consists of different combinations of five protein subunits, each produced from a different gene. These subunits form a hole (pore) in the cell membrane through which negatively charged chlorine atoms (chloride ions) can flow. A chemical that transmits signals in the brain (a neurotransmitter) called gamma-amino butyric acid (GABA) attaches to GABA A receptors. Once GABA attaches, the pore formed by the subunits opens, and chloride ions flow across the cell membrane. After infancy, chloride ions flow into the cell through the open pore, which creates an environment in the cell that blocks (inhibits) signaling between neurons. The primary role of GABA in children and adults is to prevent the brain from being overloaded with too many signals. In contrast, in newborns and infants, chloride ions flow out of the cell when the pore is opened, creating an environment that allows signaling between neurons.
Research Area
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Neuroscience
Synonyms
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Gabra1, Gabra-1