Anti-FEN1 (7H8) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
FEN1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
7H8-F4-C11
Isotype
-
IgG1
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
-
Purified recombinant human FEN-1 protein fragments expressed in E.coli.
Molecular Weight
-
Calculated MW: 43 kDa; Observed MW: 43 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
2237
Uniprot ID
-
P39748
Background
-
Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1