Anti-FAK (3D8) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PTK2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3D8-H11-E12
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Immunogen
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Purified recombinant human FAK protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 119 kDa; Observed MW: 125 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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5747
Uniprot ID
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Q05397
Background
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This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.
Research Area
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Cardiovascular
Synonyms
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PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK