Anti-ERG Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
ERG
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
ZN76
Isotype
-
IgG2a
Reactivity
Application
Application Details
-
IHC: 1/50-1/100
Immunogen
-
Full length human recombinant protein of human ERG(NP_891548) produced in HEK293T cell.
Molecular Weight
-
-
Formulation
-
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Form
-
Liquid
Gene ID
-
2078
Uniprot ID
-
P11308
Background
-
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
ERG; Transcriptional regulator ERG；Transforming protein ERG