Anti-ERCC1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ERCC1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-7E3
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthetic peptide of human ERCC1
Molecular Weight
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Calculated MW: 33 kDa; Observed MW: 39 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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2067
Uniprot ID
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P07992
Background
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DNA repair systems operate in all living cells to manage a variety of DNA lesions. Nucleotide excision repair (NER) is implemented in cases where bulky helix-distorting lesions occur, such as those brought about by UV and certain chemicals. Research studies have shown that expression of ERCC1 is related to survival rate and response to chemotherapeutic drugs in several human cancers including non-small cell lung cancer (NSCLC).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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ERCC1; DNA excision repair protein ERCC-1