Anti-ErbB 3 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ERBB3
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-3O-3
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/100-1/200
Immunogen
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A synthesized peptide derived from human ERBB3
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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2065
Uniprot ID
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P21860
Background
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This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.
Research Area
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Cell Biology
Synonyms
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ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3