Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody

Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody
Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody
Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody
Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody

Anti-EGFR(L747-P753 Mutant)S Mouse Monoclonal Antibody

Mouse IgG Monoclonal for EGFR,HER1,ERBB1 detection, Test with WB, IHC-P, ICC/IF, ELISA in Vertebrates

Reactivity
  • Vertebrates
Application
  • WB
  • IHC-P
  • ICC
  • IF
  • ELISA
Host
  • Mouse
Catalog Number
    ABXB07317
$680.00

Shipping To:
United States

Product Information

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Target
    EGFR,HER1,ERBB1
Host
  • Mouse
Storage
    Store at -20°C. Avoid repeated freezing and thawing
Clonality
  • Monoclonal
Clone Number
    3C4-S2-W3
Isotype
    IgG
Reactivity
  • Vertebrates
Application
  • WB
  • IHC-P
  • ICC
  • IF
  • ELISA
Application Details
    ELISA: 1/1000-1/5000,WB: 1/500-1/1000,IHC-P: 1/50-1/100
Immunogen
    A synthetic peptide from the internal region of EGFR which includes the mutation of (L747-P753) S, human origin.
Formulation
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
    Liquid
Uniprot ID
    ­
Background
    EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).
Research Area
    Signal Transduction
Synonyms
    EGFR,HER1,ERBB1
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Product Image

Western blot analysis of recombinant EGFR(L747-P753) S and wild type proteins.Purified His-tagged EGFR(L747-P753)S protein (702-987) and wild type protein (702-987) were blotted with anti- EGFR(L747-P753)S mouse.
Immunofluorescence of cells expressing EGFR proteins with anti-EGFR(L747-P753)S.HEK293T cells were transfected with pCDNA3-GFP-EGFR (WT) plasmid (left column) or pCDNA3-GFP-EGFR(L747-P753)S plasmid (right column), then fixed and stained with anti- EGFR(L747-P753)S monoclonal.