Anti-EGFR(E746-A750 Mutant)del Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
EGFR,HER1,ERBB1
Host
Storage
-
Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
-
3E3-P5-R2
Reactivity
Application
Application Details
-
ELISA: 1/1000-1/5000,WB: 1/500-1/1000
Immunogen
-
A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin.
Formulation
-
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
-
Liquid
Uniprot ID
-
Background
-
EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).
Research Area
-
Signal Transduction
Synonyms
-
EGFR,HER1,ERBB1