Anti-EGFR Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
EGFR
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/50-1/100
Immunogen
-
Recombinant protein of human EGFR (NP_005219.2).
Molecular Weight
-
Calculated MW: 134 kDa; Observed MW: 130-180 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.01% thiomersal, pH 7.3.
Form
-
Liquid
Gene ID
-
1956
Uniprot ID
-
P00533
Background
-
EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.
Research Area
-
Signal Transduction
Synonyms
-
EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1