Anti-EGFR Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
EGFR
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
5H1-R8-U6
Isotype
-
IgG1
Reactivity
Application
Application Details
-
WB-1:500-1:1000; IHC-1:100-1:200; FC-1:50-1:100; ELISA-1:10000
Immunogen
-
Purified recombinant fragment of human EGFR expressed in E. Coli.
Molecular Weight
-
Calculated MW: 134 kDa;Observed MW: 175 kDa
Formulation
-
Purified antibody in PBS with 0.05% sodium azide
Form
-
Liquid
Gene ID
-
1956
Uniprot ID
-
P00533
Background
-
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Research Area
-
Signal Transduction
Synonyms
-
EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1