Anti-DOK1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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DOK1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-2Y2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human DOK1
Molecular Weight
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Calculated MW: 52 kDa; Observed MW: 65 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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1796
Uniprot ID
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Q99704
Background
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DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Research Area
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Signal Transduction
Synonyms
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DOK1; Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62