Anti-DOHH Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
DOHH
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R04-4I8
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/20
Immunogen
-
A synthetic peptide of human DOHH
Molecular Weight
-
Calculated MW: 33 kDa; Observed MW: 33 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
83475
Uniprot ID
-
Q9BU89
Background
-
Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function .
Research Area
-
Signal Transduction
Synonyms
-
HLRC1; hDOHH