Anti-DOCK2 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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DOCK2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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ZN142
Isotype
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IgG2a
Reactivity
Application
Application Details
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IHC: 1/50-1/100
Immunogen
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Human recombinant protein fragment of human DOCK2 (NP_004937) produced in E.coli.
Molecular Weight
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-
Formulation
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PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Form
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Liquid
Gene ID
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1794
Uniprot ID
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Q92608
Background
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The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Research Area
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Signal Transduction
Synonyms
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DOCK 2; Dedicator of cytokinesis protein 2; KIAA0209