Anti-Dnmt3b Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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DNMT3B
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-7G6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human Dnmt3b
Molecular Weight
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Calculated MW: 96 kDa; Observed MW: 97 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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1789
Uniprot ID
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Q9UBC3
Background
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Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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Dnmt3b; DNA methyltransferase HsaIIIB; DNMT3B