Anti-Dnmt3a Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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DNMT3A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R03-8H4
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthetic peptide of human Dnmt3a
Molecular Weight
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Calculated MW: 102 kDa; Observed MW: 130 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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1788
Uniprot ID
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Q9Y6K1
Background
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Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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DNMT3A2; M.HsaIIIA; Dnmt3a; MCMT; DNA methyltransferase 3a