Anti-DiMethyl-Histone H3 (Lys27) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H3C1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-2Y-2
Isotype
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IgG/Kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000 ICC/IF: 1/50-1/200
Immunogen
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Peptide
Molecular Weight
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-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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8350
Uniprot ID
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P68431
Background
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The ε-amino lysine methylation of proteins is an important reversible modification controlling protein activity. The amino-terminal tails of core histones undergo lysine methylation in multiple sites, termed as “histone code” or “epigenetic code”. Lysine methylation in core histones is a major determinant for theformation of active and inactive regions of the genome and therefore playsvital roles in multiple cellular events. In most species, lysine methylationoccurs primarily on histones H3 (Lys4, 9, 27, 36, 79), and H4 (Lys20) and hasbeen implicated in both transcriptional activation and silencing. Methylation in histones modulated by specific histone methylases (HMTs) and histone demethylases (HDMs). The level of methyllysineis found impaired in the pathologies of cancers and other diseases, therefore, enzymes regulating histone lysine methylation have become promising targets for anti-cancer drugs.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H3K27me2; Histone H3/b；Histone H3/c；Histone H3/d；Histone H3/f