Anti-Cyclooxygenase 2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PTGS2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R05-2I3
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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Recombinant protein of human COX2/Cyclooxygenase 2
Molecular Weight
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Calculated MW: 69 kDa; Observed MW: 74 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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5743
Uniprot ID
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P35354
Background
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Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Research Area
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Cardiovascular
Synonyms
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COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS