Anti-Cyclin H (1A7) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CCNH
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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1A7-B5-D4
Isotype
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IgG2b
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human Cyclin H protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 38 kDa; Observed MW: 38 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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902
Uniprot ID
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P51946
Background
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Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Research Area
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Cell Biology
Synonyms
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CCNH; Cyclin-H; MO15-associated protein; p34; p37