Anti-CTNNB1(S37F Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Beta-catenin, CTNNB, Catenin beta-1
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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3S7-A7-N9
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000 WB: 1/500-1/1000 IHC-P: 1/50-1/100
Immunogen
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A synthetic peptide from the internal region of CTNNB1 which includes the mutation of S37F, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherents junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutations of CTNNB1 have been implicated in the pathogenesis of several cancers.
Research Area
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Signal Transduction
Synonyms
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Beta-catenin, CTNNB, Catenin beta-1