Anti-CSF-1R Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CSF1R
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-1R-8
Isotype
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IgG
Reactivity
Application
Application Details
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IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 109 kDa; Observed MW:109 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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1436
Uniprot ID
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P07333
Background
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Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.
Research Area
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Cell Biology
Synonyms
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CSF-1R, M-CSF-R, CD115, CSF1R, FMS