Anti-CS1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
SLAMF7
Host
Storage
-
Store at -20°C to -80°C for 12 months in lyophilized form.
Clonality
Clone Number
-
R09-5U-7
Isotype
-
IgG
Reactivity
Application
Application Details
-
FC: 1/50-1/100 ELISA: 1/10000
Immunogen
-
Recombinant human CS1 protein
Molecular Weight
-
-
Formulation
-
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Form
-
Lyophilized
Gene ID
-
57823
Uniprot ID
-
Q9NQ25
Background
-
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Research Area
-
Immunology
Synonyms
-
SLAM7 (19A; CD319; CRACC; CS1)