Anti-Crotonyl-Histone H4 (Lys16) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H4C1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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4U2-G9-P5
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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121504
Uniprot ID
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P62805
Background
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Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. Crotonylation of histone H4 at Lys16 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H4K16cr,