Anti-CRK Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CRK
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R83-7X-4
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/50 FC: 1/50
Immunogen
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A synthesized peptide derived from human CRKII
Molecular Weight
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Calculated MW: 34kDa;Observed MW:38kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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1398
Uniprot ID
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P46108
Background
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The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.
Research Area
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Signal Transduction
Synonyms
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CRK; CRKII; p38;