Anti-CLIC4 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
CLIC4
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R02-7A1
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
Immunogen
-
A synthetic peptide of human CLIC4
Molecular Weight
-
Calculated MW: 29 kDa; Observed MW: 29 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
25932
Uniprot ID
-
Q9Y696
Background
-
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Research Area
-
Cell Biology
Synonyms
-
CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1