Anti-Cleaved-Caspase 4/5 p20 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
CASP4
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 ELISA: 1/10000
Immunogen
-
The antiserum was produced against synthesized peptide derived from human Caspase 4/5.
Molecular Weight
-
Calculated MW: 43 kDa; Observed MW: 47,22 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
837/838
Uniprot ID
-
P49662/P51878
Background
-
CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Research Area
-
Cell Biology
Synonyms
-
TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II