Anti-Claudin 1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CLDN1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-5K9
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthesized peptide derived from human Claudin 1
Molecular Weight
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Calculated MW: 23 kDa; Observed MW: 18-22 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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9076
Uniprot ID
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O95832
Background
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The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer. Claudin-1 is expressed primarily in keratinocytes and normal mammary epithelial cells, but is absent or reduced in breast carcinomas and breast cancer cell lines.
Research Area
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Cell Biology
Synonyms
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CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein