Anti-CKMT1 (1A6) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CKMT1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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1A6-C7-G10
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human CKMT1 protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 47 kDa; Observed MW: 47 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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1159
Uniprot ID
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P12532
Background
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Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
Research Area
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Tags & Cell Markers
Synonyms
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CKMT; CKMT1; UMTCK; CKMT1A