Anti-CDKN2A/p16INK4a Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Cdkn2A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-2K1
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Immunogen
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Recombinant protein of mouse CDKN2A/p16INK4a
Molecular Weight
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Calculated MW: 18 kDa; Observed MW: 18 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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12578
Uniprot ID
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P51480
Background
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Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.CautionThe proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q64364) which is encoded by the same gene.
Research Area
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Cell Biology
Synonyms
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Cdkn2a;P16ink4a;Cyclin-dependent kinase 4 inhibitor A (CDK4I);p16-INK4a ;p16-INK4