Anti-CDC7 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CDC7
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-6D8
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human CDC7
Molecular Weight
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Calculated MW: 64 kDa; Observed MW: 70 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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8317
Uniprot ID
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O00311
Background
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DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins).
Research Area
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Cell Biology
Synonyms
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Cell division cycle 7-related protein kinase; EC 2.7.11.1; CDC7-related kinase; HsCdc7; huCdc7; CDC7; CDC7L1; Hsk1; CDC7 kinase