Anti-CDC25A Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
CDC25A
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
Fusion protein of human CDC25A
Molecular Weight
-
Calculated MW: 59 kDa; Observed MW: 59 kDa
Formulation
-
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
-
Liquid
Gene ID
-
993
Uniprot ID
-
P30304
Background
-
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Research Area
-
Cell Biology
Synonyms
-
CDC25A2