Anti-CD8 alpha Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CD8A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-6R-8
Isotype
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IgG
Reactivity
Application
Application Details
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IHC-P：1/50-1/100，FC：1/50
Immunogen
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Peptide
Molecular Weight
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–
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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925
Uniprot ID
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P01732
Background
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CD8a is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD8a serves primarily as a coreceptor for MHC class I molecule: peptide complex and its function are involved with lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). In NK-cells, the presence of CD8a homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8a homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Research Area
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Cell Biology
Synonyms
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MAL, CD8a