Anti-CD57 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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B3GAT1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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6F8-C2-S1
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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IHC-P：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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–
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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27087
Uniprot ID
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Q9P2W7
Background
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CD57, also known as HNK-1 and Leu7, is a terminally sulfated glycan carbohydrate epitope (glyco-epitope) expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans at the cell surface. CD57 is synthesized by the enzyme B3GAT1 and is present on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, as well as neural cells and striated muscle. Studies have shown that CD57 is not expressed on platelets, monocytes, granulocytes, or red blood cells. The CD57 epitope may play a role in neural cell adhesion, and characterizes unique maturation states in T and NK cells. CD57 is an important marker when studying functional immune deficiency in patients with autoimmune diseases, infectious diseases, and cancers.
Research Area
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Immunology
Synonyms
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GlcAT-P, GlcUAT-P, B3GAT1