Anti-CD45 (8C1) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Ptprc
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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8C1-9B8-2H1
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Immunogen
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Synthetic Peptide of CD45
Molecular Weight
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Calculated MW: 145 kDa; Observed MW: 145 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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19264
Uniprot ID
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P06800
Background
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Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.
Research Area
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Immunology
Synonyms
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GP180; L CA; CD45 antigen