Anti-CD4 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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CD4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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8Y8-O2-U2
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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–
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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920
Uniprot ID
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P01730
Background
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Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-
Research Area
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Tumor biology
Synonyms
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T-cell surface antigen T4/Leu-3